XEOMIN® (complexing protein free)

XEOMIN® (incobotulinumtoxinA) is an anti-wrinkle injection clinically proven to temporarily treat moderate-to-severe frown lines between eyebrows and crow’s feet (lines around the eye).

XEOMIN®, like Botox and Dysport, is a botulinum toxin type A approved to  paralyse muscles and smoothes wrinkles. While years younger than Botox (XEOMIN® was USFDA approved in 2012), XEOMIN® is just as effective as its predecessor. It uses an identical active ingredient, but there’s one main difference. 

XEOMIN® is a purified form of the neurotoxin, still blocking the signals from nerves to muscles, causing the muscles to relax. It’s manufactured in such a way that it removes foreign complexing proteins (the substance that causes resistance to treatment) from the active ingredient. Lately, they have been cases of botulinum toxin resistance in the market. Clique® Clinic is an advocate to help patients to get the right botulinum toxin done with the right dose and the right products to prevent that from happening.

At Clique, we hold strong to the principle of natural outcome that outweighs the lines, and it is important to retain certain facial expressions and movements while soften certain lines in the face. You should not lose the ability to show expression when you are treated by someone who is licensed, trained, and a medical expert in facial anatomy. 
It is important to make sure that the face will not be overly “done” or frozen.


When you squint or frown, the muscles between your eyebrows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines. Botulinum toxin type A – the active ingredient in XEOMIN®– acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN® can temporarily reduce the lines between your eyebrows.

XEOMIN® was proven effective in two randomised, double-blind, multicentre, placebo-controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years. Patients received 20 Units of XEOMIN® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment success was higher with XEOMIN®than placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, XEOMIN® received FDA approval for use in glabellar lines in 2011.

If you are an adult with moderate to severe glabellar lines, XEOMIN® may be right for you. Talk to your doctor to discuss the benefits and risks of treatment. Do not use XEOMIN® if you are allergic to botulinum toxin or any of the other ingredients in XEOMIN®. You should also not use XEOMIN® if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.

XEOMIN® may cause serious side effects, including allergic reactions. Symptoms of an allergic reaction to XEOMIN® may include: itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or seek medical help right away if you have wheezing, experience other asthma symptoms, or if you become dizzy or faint.In clinical trials of XEOMIN® for the treatment of frown lines between the eyebrows, headache was the most common side effect. XEOMIN® may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of taking XEOMIN®. If this happens, do not drive a car, operate machinery, or do other dangerous activities. Tell your doctor if you have any side effect that bothers you or that does not subside. These are not all of the possible side effects of XEOMIN®. For more information, see accompanying Important Safety Information, Medication Guide, and Full Prescribing Information, or ask your doctor.

Looking plastic or overdone is a common concern among individuals considering an in-patient treatment for moderate to severe frown lines. Talk to your certified medical aesthetic doctor. There are steps you can take to make you feel more comfortable. First, have a detailed discussion with the doctor. You want to talk through every concern you have, until you feel comfortable. Our medical aesthetic doctors, who are experienced in facial anatomy, can determine the right options for you. For example, the most widely used procedure for moderate to severe frown lines is neurotoxin injections, a class of prescription medication that has been shown to be effective in many studies. Finally, ask for an FDA-approved product, such as XEOMIN®. Individual results may vary.