What are the differences between Hyaluronic Acid (HA) fillers and Radiesse Plus (Calcium Hydroxyapatite) Biostimulators with filling effects? 

Dermal filler injections are currently the number two most commonly performed non-surgical cosmetic procedure in the US, losing out only to Botulinum Toxin A injections, which sits at the number one position. However, in Asia, it is the other way around.

If you are wondering what is the difference between Botulinum Toxin A and dermal filler injections, then you can find out more by reading up on our links here https://www.cliqueclinic.com/botulinum-toxin-type-a-botox and here https://www.cliqueclinic.com/dermal-fillers

Dermal filler injections are lunchtime procedures that can be done in less than an hour yet produce significant and long lasting results for skin rejuvenation, non-surgical rhinoplasty, eye bag treatment, as well as skin tightening.

But are all dermal fillers the same? Beyond just the brand names for Hyaluronic acid (Belotero, Juvederm, Restylane, Teosyal, Neauvia, Saypha, Maili, Kysense), how are products such as Radiesse (Calcium Hydroxyapetite) and Ellanse (Polycaprolactone) different from the rest?

Here I will try to answer some of your questions regarding dermal fillers, and prove to you that not all dermal fillers are created equal.

Hyaluronic acid dermal fillers (Belotero) 

Hyaluronic acid is a type of sugar (polysaccharide) that is naturally present in body tissues. It combines with water and swells up when in gel form, contributing to a smoothing/filling effect.

In some cases, hyaluronic acid used in dermal fillers is chemically modified (crosslinked) to make it last longer in the body. The effects of hyaluronic acid typically lasts 6 – 18 months, depending on the character and cross-linking.

There are various types of technology used to crosslink hyaluronic acid, and Belotero’s Cohesive Polydensified Matrix gives the filler the optimum characteristics of cohesivity, plasticity and elasticity1.

As a consequence, the Belotero range of hyaluronic acid dermal fillers distributes and integrates homogenously intradermally, leading to a natural, “smooth” and natural looking effect when compared to competitors.

cheek filler

Cheek filler with Belotero volume

Calcium Hydroxyapatite Biostimulators  with filling effect (Radiesse Plus) 

Calcium hydroxylapatite is a type of mineral that is commonly found in human teeth and bones. For wrinkle filling in the face or for the hand, calcium hydroxylapatite particles are suspended in a gel-like solution and injected into the area of concern.

Radiesse is unique because it provides both volume replacement and collagen stimulation as a primary mechanism of action2. The unique characteristics of Radiesse (high elasticity and viscosity, ability to induce long-term collagen formation) provide it with great versatility, and makes it ideal for a global facial approach3.

radiesse plus

Cheek filler with Radiesse Plus

So which dermal filler would be the best for me? 

Dermal fillers are simply a tool for the Aesthetic Physician to deliver your desired results. Depending on your condition, your Aesthetic Physician might choose one product versus another to achieve the desired effect, and the best approach would be to combine it with other modalities as well e.g. Ultherapy Microfocused Ultrasound.

You can parallel compare it to art: are pastels or watercolour better? Some artists may prefer one over the other, and sometimes choose a different modality when painting different things (e.g. portraits vs scenery). Modern artists might even combine the different modalities on different parts of their artwork.

In the end, what matters is how comfortable the doctor is in using that certain dermal filler, and the ability to bring out the best results with it. Aesthetic medicine is more than just medical, it is also an artistry. Be sure to choose a doctor who is not only qualified, but one whom you admire the artwork.


1. Prasetyo, A.D., Prager, W., Rubin, M.G., Moretti, E.A. and Nikolis, A., 2016. Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review. Clinical, cosmetic and investigational dermatology, 9, p.257.

2. Werschler, W.P. and Narurkar, V.N., 2006. Facial volume restoration: selecting and applying appropriate treatments. Technique poster. Cosrnet Dermatol, 19(Suppl 2), p.S1.

3. Van Loghem, J., Yutskovskaya, Y.A. and Werschler, W.P., 2015. Calcium hydroxylapatite: over a decade of clinical experience. The Journal of clinical and aesthetic dermatology, 8(1), p.38.