Drugs and Supplements

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Cough
  • Difficulty with speaking
  • Drooling
  • Fear or nervousness
  • Fever
  • Inability to sit still
  • Loss of balance control
  • Muscle trembling, jerking, or stiffness
  • Need to keep moving
  • Restlessness
  • Shuffling walk
  • Sneezing
  • Sore throat
  • Stiffness of the limbs
  • Twisting movements of the body
  • Uncontrolled movements, especially of the face, neck, and back

Less common

  • Blurred vision
  • Body aches or pain
  • Chest pain
  • Congestion
  • Dizziness
  • Fast, pounding, or irregular heartbeat or pulse
  • Headache
  • Hoarseness
  • Nervousness
  • Pounding in the ears
  • Runny nose
  • Slow or fast heartbeat
  • Swelling of the tongue
  • Tender, swollen glands in the neck
  • Trouble with swallowing
  • Voice changes

Rare

  • Fainting or feeling faint
  • Feeling faint upon standing
  • Persistent, painful erection
  • Seizures

Incidence not known

  • Inability to move the eyes
  • Increased blinking or spasms of the eyelid
  • Sticking out of tongue
  • Trouble with breathing, speaking, or swallowing
  • Uncontrolled twisting movements of the neck, trunk, arms, or legs
  • Unusual facial expressions

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Drowsiness
  • Shakiness in the legs, arms, hands, or feet
  • Sleepiness
  • Slurred speech
  • Trembling or shaking of the hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • Belching
  • Constipation
  • Diarrhea
  • Heartburn
  • Indigestion
  • Lack or loss of strength
  • Nausea
  • Rash
  • Stomach discomfort, upset, or pain
  • Weakness
  • Weight gain

Less common

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • Change in vision
  • Cracked, dry, or scaly skin
  • Depression
  • Difficulty with moving
  • Dry mouth
  • Increase in salivation
  • Itching or reddening of the skin
  • Joint pain
  • Loss of appetite
  • Muscle ache
  • Muscle pains or stiffness
  • Muscle tightness
  • Stuffy nose
  • Swelling
  • Swollen joints
  • Vomiting
  • Weakness of the arms and legs
  • Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine can cause changes in the heart rhythm, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects. Call your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Stop taking this medicine and check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs while you are using this medicine.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

Ziprasidone can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.

If you develop a skin rash, hives, or any allergic reaction to this medicine, stop using the medicine and check with your doctor as soon as possible.

This medicine may cause some people to become drowsy or dizzy, or to have trouble with thinking or controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, or able to think well.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

Avoid activities involving high temperature or humidity. This medicine may reduce your body’s ability to adjust to the heat.

Ziprasidone may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies. If you or your caregiver notice any of these side effects, tell your doctor right away.

Avoid drinking alcohol while you are using this medicine.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine. Talk to your doctor about ways to prevent weight gain.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Proper Use

Take this medicine only as directed by your doctor even if you feel well. Do not take more of this medicine and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep blood levels constant, take this medicine at the same time each day and do not miss any doses.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Swallow the capsule whole. Do not split, crush, or chew it.

You may take this medicine with food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For bipolar disorder:
      • Adults—At first, 40 milligrams (mg) two times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg two times per day.
      • Children—Use and dose must be determined by your doctor.
    • For schizophrenia:
      • Adults—At first, 20 milligrams (mg) two times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg two times per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ziprasidone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ziprasidone in the elderly. However, this medicine should not be used for behavioral problems in older adults with dementia.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acecainide
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Aprindine
  • Arsenic Trioxide
  • Astemizole
  • Azimilide
  • Bepridil
  • Bretylium
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Crizotinib
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dronedarone
  • Droperidol
  • Enflurane
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Foscarnet
  • Gatifloxacin
  • Gemifloxacin
  • Halofantrine
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Isoflurane
  • Isradipine
  • Levomethadyl
  • Lidoflazine
  • Lorcainide
  • Mefloquine
  • Mesoridazine
  • Methadone
  • Metoclopramide
  • Moxifloxacin
  • Octreotide
  • Pentamidine
  • Pimozide
  • Pirmenol
  • Posaconazole
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Quinidine
  • Saquinavir
  • Sematilide
  • Sertindole
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Spiramycin
  • Sultopride
  • Tacrolimus
  • Tedisamil
  • Telithromycin
  • Terfenadine
  • Thioridazine
  • Toremifene
  • Trifluoperazine
  • Vandetanib
  • Vasopressin
  • Vemurafenib
  • Zolmitriptan
  • Zotepine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ajmaline
  • Amitriptyline
  • Amoxapine
  • Arsenic Trioxide
  • Azithromycin
  • Chlorpromazine
  • Desipramine
  • Disopyramide
  • Doxepin
  • Fluoxetine
  • Haloperidol
  • Hydromorphone
  • Hydroquinidine
  • Iloperidone
  • Imipramine
  • Lapatinib
  • Levofloxacin
  • Lumefantrine
  • Milnacipran
  • Nilotinib
  • Nortriptyline
  • Pazopanib
  • Pirmenol
  • Prajmaline
  • Procainamide
  • Prochlorperazine
  • Protriptyline
  • Quetiapine
  • Ranolazine
  • Sunitinib
  • Telavancin
  • Tetrabenazine
  • Trifluoperazine
  • Trimipramine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alzheimer’s disease or dementia or
  • Bradycardia (slow heartbeat) or
  • Dehydration or
  • Heart attack, history of or
  • Heart failure or
  • Heart or blood vessel disease or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low amount of blood) or
  • Stroke, history of or
  • Trouble with swallowing—May cause side effects to become worse.
  • Blood or bone marrow problems (e.g., agranulocytosis, leukopenia, neutropenia) or
  • Breast cancer, prolactin-dependent or
  • Diabetes mellitus or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Neuroleptic malignant syndrome (NMS), history of or
  • Priapism (painful or prolonged erection of the penis) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Heart attack, recent or
  • Heart failure, uncompensated or
  • Heart rhythm problems (e.g., arrhythmia, QT prolongation), history of—Should not be used in patients with these conditions.

Description

Ziprasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia, mania, or bipolar disorder. This medicine should not be used to treat behavioral problems in elderly patients who have dementia.

This medicine is available only with your doctor’s prescription.

June 23, 2015

Ziprasidone

Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Cough Difficulty with speaking Drooling Fear or nervousness Fever Inability to sit still Loss of balance control Muscle trembling, jerking, or stiffness Need to keep moving Restlessness Shuffling walk Sneezing Sore throat Stiffness of the limbs Twisting movements of the body Uncontrolled movements, especially of the face, neck, and back Less common Blurred vision Body aches or pain Chest pain Congestion Dizziness Fast, pounding, or irregular heartbeat or pulse Headache Hoarseness Nervousness Pounding in the ears Runny nose Slow or fast heartbeat Swelling of the tongue Tender, swollen glands in the neck Trouble with swallowing Voice changes Rare Fainting or feeling faint Feeling faint upon standing Persistent, painful erection Seizures Incidence not known Inability to move the eyes Increased blinking or spasms of the eyelid Sticking out of tongue Trouble with breathing, speaking, or swallowing Uncontrolled twisting movements of the neck, trunk, arms, or legs Unusual facial expressions Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Drowsiness Shakiness in the legs, arms, hands, or feet Sleepiness Slurred speech Trembling or shaking of the hands or feet Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you […]
June 23, 2015

Ziprasidone

Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Chills Cold sweats Confusion Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position Less common Anxiety Bleeding from rectum or bloody stools Blurred vision Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings Change in personality Chest pain or discomfort Cough Diarrhea Difficulty with speaking Drooling Dry mouth Excessive muscle tone Feeling of warmth or heat Feeling that others are watching you or controlling your behavior Feeling that others can hear your thoughts Feeling, seeing, or hearing things that are not there Fever Flushing or redness of the skin, especially on the face and neck General feeling of discomfort or illness Headache Hyperventilation Incremental or ratchet-like movement of the muscles Irregular heartbeats Irritability Joint pain Loss of appetite Loss of balance control Multiple swollen and inflamed skin lesions Muscle aches and pains Muscle discomfort Muscle tension or tightness Muscle trembling, jerking, or stiffness Nausea Nervousness Painful or prolonged erection of the penis Pounding in the ears Restlessness Rigid or stiff muscles Runny nose Severe mood or mental changes Shaking Shivering Shortness of breath Shuffling walk Slow or fast heartbeat Sore throat Stiffness of the limbs Sweating Trouble sleeping Twisting movements of the body Uncontrolled movements, especially of the face, neck, and back Unusual behavior Unusual tiredness or weakness Vomiting Rare Actions that are out of control Convulsions Difficulty with breathing Fainting Fast, pounding, or irregular heartbeat or pulse High fever High or low blood pressure Hives Itching Lip smacking or puckering Loss of bladder […]
June 23, 2015

Zoledronic Acid

Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Agitation Black, tarry stools Blurred vision Chest pain Chills Coma Confusion Convulsions Cough Depression Difficult or labored breathing Dizziness Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position Fever Irregular heartbeat Irritability Lack or loss of strength Lethargy Lower back or side pain Mood or mental changes Muscle pain or cramps Muscle trembling or twitching Nausea or vomiting Numbness and tingling around the mouth, fingertips, or feet Painful or difficult urination Pale skin Rapid weight gain Seizures Shaking of the hands, arms, feet, legs, or face Shortness of breath Skin rash, cracks in the skin at the corners of the mouth, or soreness or redness around the fingernails and toenails Sore throat Sores, ulcers, or white spots on the lips or mouth Stupor Sudden sweating Swollen glands Tightness in the chest Trouble breathing with exercise Unusual bleeding or bruising Unusual tiredness or weakness Wheezing Less common Feeling of constant movement of self or surroundings Muscle cramps in the hands, arms, feet, legs, or face Muscle spasms Neck pain Pounding in the ears Rapid breathing Sensation of spinning Slow or fast heartbeat Sunken eyes Tingling of the hands or feet Tremor Incidence not known Blurred vision or other change in vision Decreased frequency or amount of urine Decreased vision Eye pain Eye tenderness Heavy jaw feeling Increased blood pressure Increased tearing Increased thirst Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs Loosening of a tooth Pain, swelling, or numbness […]
June 23, 2015

Zolmitriptan

Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Stop taking this medicine and get emergency help immediately if any of the following effects occur: More common Chest pain (severe) Heaviness, tightness, or pressure in chest and/or neck Sensation of burning, warmth, heat, numbness, tightness, or tingling Less common or rare Abdominal pain (severe) Changes in facial skin color Cough or hoarseness Diarrhea Fast or irregular heartbeat Fever or chills Loss of appetite Lower back or side pain Nausea Painful or difficult urination Puffiness or swelling of the eyelids or around the eyes, face, or lips Shortness of breath, troubled breathing, tightness in chest, and/or wheezing Skin rash, hives, and/or itching Weakness Other side effects may occur that usually do not need medical attention. Some of the following effects, such as nausea, vomiting, drowsiness, dizziness, and general feeling of illness or tiredness, often occur during or after a migraine, even when zolmitriptan has not been used. However, check with your doctor if any of the following side effects continue or are bothersome: More common Dizziness Nausea Sleepiness Unusual tiredness or muscle weakness Less common Agitation Anxiety Depression Discomfort in jaw, mouth, or throat Difficulty in swallowing Dry mouth Fainting Heartburn Itching of the skin Large nonelevated blue or purplish patches in the skin Muscle aches Pounding heartbeat Sudden large increase in frequency and quantity of urine Sweating Swelling of face, fingers, feet and/or lower legs Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Precautions […]
June 23, 2015

Zolpidem

Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Clumsiness or unsteadiness Confusion Mental depression Rare Dizziness, lightheadedness, or fainting Falling Fast heartbeat Hallucinations (seeing, hearing, or feeling things that are not there) Skin rash Swelling of the face Trouble with sleeping Unusual excitement, nervousness, or irritability Wheezing or difficulty with breathing Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Clumsiness or unsteadiness (severe) Dizziness (severe) Double vision or other vision problems Drowsiness (severe) Nausea (severe) Slow heartbeat Troubled breathing Vomiting (severe) Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Sleepiness or unusual drowsiness Less common Abdominal or stomach pain Abnormal or decreased touch sensation Abnormal sensation of movement Appetite disorder Balance disorder Binge eating Bladder pain Bloated Bloody or cloudy urine Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings Change in hearing Chest discomfort Chills Confusion about identity, place, and time Constipation Continuing ringing or buzzing or other unexplained noise in the ears Daytime drowsiness Diarrhea Difficult, burning, or painful urination Difficulty with moving Difficulty with swallowing Discouragement Double vision or other vision problems Drugged feelings Dryness of mouth Ear drainage Earache […]
June 23, 2015

Zonisamide

Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Discouragement Feeling sad or empty Irritability Lack of appetite Loss of interest or pleasure Mood or mental changes Shakiness or unsteady walking Tiredness Trouble with concentrating Trouble with sleeping Less common Agitation Bruising Delusions Hallucinations Large, flat blue or purplish patches on the skin Rash Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Difficult or labored breathing Faintness Loss of consciousness Slow or irregular heartbeat Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain Anxiety Difficulty with memory Dizziness Double vision Headache Loss of appetite Nausea Restlessness Sleepiness Sleeplessness Unusual drowsiness Unusual tiredness or weakness Less common Aching muscles or joints Acid or sour stomach Bad, unusual, or unpleasant taste in the mouth Belching Change in taste Chills Constipation Diarrhea Difficulty with speaking Difficulty with thinking Dry mouth Fever General ill feeling Headache Heartburn Indigestion Mental slowness Nervousness Runny or stuffy nose Sneezing Tingling, burning, or prickly feelings on the skin Uncontrolled, back and forth, or rolling eye movements Weight loss Other side effects not listed may also occur in some patients. If you […]