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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:


  • Faintness
  • Itching, redness, or swelling at place of injection
  • Skin rash
  • Tightness of throat
  • Wheezing

Symptoms of overdose

  • Chest pain
  • Fast or irregular heartbeat
  • Irritability
  • Nervousness
  • Shortness of breath
  • Sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Flushing of face
  • Frequent urge to urinate
  • Headache
  • Nausea and vomiting
  • Stomach discomfort

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Proper Use

For your doctor to properly treat your medical condition, you must receive every dose of this medicine. After the last dose, the doctor may want to perform certain tests that are very important.

It is important that your doctor check your progress to make sure that this medicine is working properly and to check for unwanted effects.


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For testing the thyroid gland:
      • Adults and children—10 International Units (IU) injected under the skin or into a muscle once a day for one to three days. If thyroid testing is being done after surgery, this medicine will usually be given for three to seven days.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults.


Many medicines have not been studied specifically in the elderly. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of thyrotropin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.


Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Hardening of the arteries or
  • Heart disease or
  • High blood pressure—Thyrotropin increases body metabolism and causes the heart to work harder, which may make these conditions worse
  • Untreated underactive adrenal gland or
  • Untreated underactive pituitary gland—Use of thyrotropin may severely worsen these conditions


Thyrotropin is used in a test to determine how well your thyroid is working. It may also be used for other conditions as determined by your doctor.

Thyrotropin is to be administered only by or under the immediate supervision of your doctor.