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Propranolol

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  • Abdominal or stomach pain and tenderness
  • Black, tarry stools
  • Blistering, peeling, or loosening of the skin
  • Blood in the urine
  • Bloody nose
  • Bloody stools
  • Blurred or loss of vision
  • Body aches or pain
  • Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • Chest pain or discomfort
  • Confusion about identity, place, and time
  • Congestion
  • Constipation
  • Cough
  • Cracks in the skin
  • Crying
  • Decreased awareness or responsiveness
  • Decreased urine output
  • Depersonalization
  • Diarrhea
  • Difficulty with breathing or swallowing
  • Difficulty with swallowing
  • Dilated neck veins
  • Disturbed color perception
  • Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • Double vision
  • Dryness or soreness of the throat
  • Dysphoria
  • Euphoria
  • Extreme fatigue
  • Fast, pounding, slow, or irregular heartbeat
  • Fever and chills
  • General feeling of discomfort, illness, or weakness
  • Hair loss
  • Halos around lights
  • Headaches
  • Heavier menstrual periods
  • Hives
  • Hoarseness
  • Irregular breathing
  • Itching
  • Lightheadedness, dizziness, or fainting
  • Loss of heat from the body
  • Mental depression
  • Mimicry of speech or movements
  • Muscle or joint pain
  • Mutism
  • Nausea
  • Negativism
  • Night blindness
  • Noisy breathing
  • Overbright appearance of lights
  • Paleness or cold feeling in the fingertips and toes
  • Paranoia
  • Peculiar postures or movements, mannerisms, or grimacing
  • Pinpoint red or purple spots on the skin
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Quick to react or overreact emotionally
  • Rapidly changing moods
  • Rectal bleeding
  • Red skin lesions, often with a purple center
  • Red, irritated eyes
  • Red, swollen skin
  • Reddening of the skin, especially around the ears
  • Runny nose
  • Scaly skin
  • Seeing, hearing, or feeling things that are not there
  • Severe sleepiness
  • Short-term memory loss
  • Shortness of breath
  • Skin irritation or rash, including rash that looks like psoriasis
  • Skin rash
  • Sores, ulcers, or white spots in the mouth or on the lips
  • Sweating
  • Swelling of the eyes, face, fingers, feet, or lower legs
  • Swollen glands
  • Tender, swollen glands in the neck
  • Tightness in the chest
  • Tingling or pain in fingers or toes when exposed to cold
  • Trouble with swallowing
  • Troubled breathing
  • Tunnel vision
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Voice changes
  • Vomiting
  • Weight gain
  • Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Dry eyes
  • Heartburn
  • Loss of strength or energy
  • Muscle weakness
  • Pain or discomfort in the chest, upper stomach, or throat
  • Sleeplessness
  • Stomach cramps
  • Trouble sleeping
  • Unable to sleep
  • Unusual drowsiness, dullness, or feeling of sluggishness
  • Vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. .

Propranolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. Do not stop taking this medicine before surgery without your doctor’s approval.

This medicine may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking propranolol.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in your mouth or lips; or unusual tiredness or weakness.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Propranolol will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propranolol capsules, extended-release capsules, and tablets in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of propranolol oral solution in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propranolol in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propranolol.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Albuterol
  • Amiodarone
  • Arformoterol
  • Bambuterol
  • Bitolterol
  • Broxaterol
  • Bupivacaine
  • Clenbuterol
  • Clonidine
  • Colterol
  • Diatrizoate
  • Diltiazem
  • Dronedarone
  • Epinephrine
  • Fenoldopam
  • Fenoterol
  • Formoterol
  • Haloperidol
  • Hexoprenaline
  • Indacaterol
  • Isoetharine
  • Levalbuterol
  • Lidocaine
  • Mefloquine
  • Mepivacaine
  • Metaproterenol
  • Pirbuterol
  • Prilocaine
  • Procaterol
  • Reproterol
  • Rimiterol
  • Ritodrine
  • Salmeterol
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetohexamide
  • Alclofenac
  • Alfuzosin
  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Amlodipine
  • Apazone
  • Arbutamine
  • Benfluorex
  • Benoxaprofen
  • Bromfenac
  • Bufexamac
  • Bunazosin
  • Calcium Carbonate
  • Carprofen
  • Chlorpromazine
  • Chlorpropamide
  • Cimetidine
  • Clometacin
  • Clonixin
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digoxin
  • Dihydroergotamine
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Dipyrone
  • Disopyramide
  • Doxazosin
  • Droxicam
  • Ergotamine
  • Etodolac
  • Etofenamate
  • Felbinac
  • Felodipine
  • Fenbufen
  • Fenoprofen
  • Fentiazac
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fluvoxamine
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Guggul
  • Ibuprofen
  • Indomethacin
  • Indoprofen
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Isoxicam
  • Ketoprofen
  • Ketorolac
  • Lacidipine
  • Lercanidipine
  • Lornoxicam
  • Magaldrate
  • Manidipine
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Mibefradil
  • Miglitol
  • Moxisylyte
  • Nabumetone
  • Naproxen
  • Nicardipine
  • Nifedipine
  • Niflumic Acid
  • Nilvadipine
  • Nimesulide
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Oxaprozin
  • Oxyphenbutazone
  • Phenoxybenzamine
  • Phentolamine
  • Phenylbutazone
  • Phenylephrine
  • Piperine
  • Pirazolac
  • Piroxicam
  • Pirprofen
  • Pranidipine
  • Prazosin
  • Propoxyphene
  • Propyphenazone
  • Proquazone
  • Quinidine
  • Repaglinide
  • Rifapentine
  • Rizatriptan
  • Sertraline
  • St John’s Wort
  • Sulindac
  • Suprofen
  • Tamsulosin
  • Tenidap
  • Tenoxicam
  • Terazosin
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolmetin
  • Trimazosin
  • Troglitazone
  • Tubocurarine
  • Urapidil
  • Zileuton
  • Zomepirac

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anaphylactic reaction (severe), history of—May increase risk for repeated anaphylactic reactions.
  • Angina (severe chest pain) or
  • Glaucoma or
  • Heart attack, recent or
  • Muscle problems (e.g., myopathy, myotonia)—Use with caution. May make these conditions worse.
  • Asthma or
  • Bradycardia (slow heartbeat) or
  • Cardiogenic shock (shock caused by heart attack) or
  • Heart block or
  • Heart failure or
  • Sick sinus syndrome (type of abnormal heart rhythm) or
  • Tremors due to Parkinson’s disease—Should not be used in patients with these conditions.
  • Diabetes or
  • Hyperthyroidism (overactive thyroid) or
  • Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal from the body.
  • Lung disease (e.g., bronchitis, emphysema)—Use with caution. May cause difficulty with breathing in patients with this condition.
  • Tachycardia (fast heartbeat) or
  • Wolff-Parkinson-White syndrome (rare heart condition)—May cause very slow heartbeat in patients with these conditions.

Description

Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Propranolol is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle).

This medicine may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). It may also be used to reduce the risk of death in patients who have heart attacks.

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

This medicine is available only with your doctor’s prescription.